Rnai-mediated inhibition of spleen tyrosine kinase-related...

Details Rnai-mediated inhibition of spleen tyrosine kinase-related... Rnai-mediated inhibition of spleen tyrosine kinase-related...

A - Human Necessities

61

K

A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2649138

RNA interference is provided for inhibition of spleen tyrosine kinase (Syk) mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease.

L'invention concerne une interférence de l'ARN assurant l'inhibition de l'expression de l'ARNm de la tyrosine kinase de rate (Syk), en particulier pour traiter des patients ayant une condition inflammatoire apparentée à Syk ou étant à risque de développer une condition inflammatoire apparentée à Syk telle que la conjonctivite allergique, l'inflammation oculaire, la dermatite, la rhinite, l'asthme, l'allergie ou une maladie des mastocytes.

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