C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) C07H 21/02 (2006.01)
Patent
CA 2650416
RNA interference is provided for inhibition of tumor necrosis factor .alpha. (TNF.alpha.) by silencing TNF.alpha. cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNF.alpha. converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNF.alpha. targets, in particular, is useful for treating patients having a TNF.alpha.-related condition or at risk of developing a TNF.alpha.-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.
L'invention porte sur une ARN interférence qui permet d'inhiber le facteur de nécrose tumorale .alpha. ("tumor necrosis factor .alpha." ou TNF.alpha.) en bloquant l'expression de l'ARNm du récepteur de surface cellulaire appelé récepteur TNF 1 (TNFR1), ou en bloquant l'expression de l'ARNm de l'enzyme de conversion du TNF.alpha. (TACE/ADAM17). Le blocage de ces cibles de TNF.alpha. s'avère particulièrement utile dans le traitement de patients souffrant d'un état lié au TNF.alpha. ou susceptibles de développer un état lié au TNF.alpha., tel qu'un état de sécheresse oculaire, de conjonctivite allergique ou d'inflammation oculaire, ou tel qu'une dermatite, une rhinite ou de l'asthme, par exemple.
Chatterton Jon E.
Gamache Daniel A.
Miller Steven T.
Senchyna Diane Michelle
Yanni John M.
Alcon Research Ltd.
Smart & Biggar
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