Rnai modulation of mll-af4 and uses thereof

Details Rnai modulation of mll-af4 and uses thereof Rnai modulation of mll-af4 and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2590768

The invention relates to compositions and methods for modulating the expression of the MLL-AF4 fusion gene, and more particularly to the downregulation of MLL-AF4 by chemically modified oligonucleotides.

L'invention concerne des compositions et des méthodes permettant de moduler l'expression du gène de fusion MLL-AF4 et, plus particulièrement, la régulation négative de MLL-AF4 au moyen d'oligonucléotides chimiquement modifiés.

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