A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01)
Patent
CA 2584309
The present invention is based on the in vivo demonstration that RSV and PIV can be inhibited through intranasal administration of RNAi agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV or PIV mRNA levels, RSV or PIV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.
La présente invention repose sur la démonstration in vivo que le virus respiratoire syncytial (RSV) et le virus parainfluenza (PIV) peuvent s'inhiber par administration intranasale d'agents ARN interférence ainsi que par administration parentérale de tels agents. En outre, il est apparu qu'on peut obtenir une réduction virale effective en traitant plusieurs virus simultanément. Partant de ces faits, la présente invention propose des compositions générales et spécifiques et des procédés convenant pour la réduction des niveaux d'ARN messager de RSV et PIV, des niveaux de protéines de RSV ou de PIV, et des titrages viraux chez un sujet par exemple un mammifère, tel qu'un humain. Ces faits sont applicables à d'autres virus respiratoires.
Smart & Biggar
South Alabama Medical Science Foundation
LandOfFree
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