Rnai modulation of scap and therapeutic uses thereof

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/63 (2006.01) A61K 31/713 (2006.01) C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) A61K 48/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2663803

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell.

ARN double brin (ARNds) inhibant l'expression d'un gène SCAP (gène SCAP humain), comprenant un brin antisens à séquence nulcéotidique de longueur inférieure à 30 nucléotides, en général entre 19 et 25, et sensiblement complémentaire avec au moins une partie de gène SCAP. Également, composition pharmaceutique comprenant l'ARNds et un vecteur pharmaceutiquement acceptable, et enfin procédés de traitement de maladies causées par l'expression du gène SCAP humain et l'expression d'un gène SCAP, reposant sur l'utilisation de ladite composition; et procédés d'inhibition de l'expression d'un gène SCAP dans une cellule.

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