Rnai modulation of the bcr-abl fusion gene and uses thereof

Details Rnai modulation of the bcr-abl fusion gene and uses thereof Rnai modulation of the bcr-abl fusion gene and uses thereof

A - Human Necessities

61

K

A61K 48/00 (2006.01)

Patent

CA 2587697

The invention relates to compositions and methods for modulating the expression of Bcr-Abl, and more particularly to the down-regulation of Bcr-Abl mRNA and Bcr-Abl protein levels by oligonucleotides via RNA interference, e.g., chemically modified oligonucleotides.

L'invention concerne des compositions et des procédés pour moduler l'expression de Bcr-Abl, et plus particulièrement la diminution d'ARNm Bcr-Abl et de la protéine Bcr-Abl dans des oligonucléotides par interférence ARN, à savoir, des oligonucléotides chimiquement modifiées.

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