C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/712 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2494766
RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and - 5 simultaneously, Mitf, and B-raf. The invention further provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual, including a human individual in need of such treatment.
La présente invention concerne des séquences d'ARN interférant qui conviennent comme moyens thérapeutiques pour le traitement de divers types de cancers, et notamment le cancer de la prostate, les sarcomes tels que l'ostéosarcome, l'hypernéphrome, le cancer du sein, le cancer de la vessie, le cancer du poumon, le cancer du colon, le cancer de l'ovaire, les lymphomes et mélanomes à grandes cellules anaplasiques, et la maladie d'Alzheimer. Ces séquences ciblent la clusterine, l'IGFBP-5, l'IGFBP-2, les deux IGFBP-2 et -5 simultanément, le Mitf, et le B-raf. L'invention concerne également l'utilisation de ces séquences d'ARN interférant pour le traitement de divers types de cancers, et notamment le cancer de la prostate, les sarcomes tels que l'ostéosarcome, l'hypernéphrome, le cancer du sein, le cancer de la vessie, le cancer du poumon, le cancer du colon, le cancer de l'ovaire, les lymphomes et mélanomes à grandes cellules anaplasiques, et la maladie d'Alzheimer, mais aussi un procédé permettant de traiter de tels états par administration de ces molécules d'ARN présentant une activité d'ARN interférant, à un individu, y compris humain, nécessitant un tel traitement.
Beraldi Eliana
Gleave Martin E.
Gonos Efstathios S.
Jansen Burkhard
Signaevsky Maxim
Smart & Biggar
The University Of British Columbia
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