C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2304926
Robot and Robot polypeptides may be produced recombinantly from transformed host cells from the disclosed Robo encoding nucleic acids or purified from human cells. The invention provides isolated Robo hybridization probes and primers capable of specifically hybridizing with the disclosed Robo genes, Robo-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
Il est possible d'obtenir par recombinaison les polypeptides Robo 1 et Robo 2 à partir de cellules hôtes transformées des acides nucléiques codant les polypeptides Robo considérés, ou bien sous forme purifiée à partir de cellules humaines. L'invention concerne également des sondes et des amorces d'hybridation pour les polypeptides Robo isolés, qui peuvent offrir une hybridation spécifique avec les gènes Robo considérés. L'invention concerne en outre des agents de liaison spécifiques pour Robo (par exemple, anticorps spécifiques), et des procédés relatifs à la fabrication et à l'utilisation des compositions décrites, aux fins de diagnostic et de thérapie ainsi que dans l'industrie biopharmaceutique.
Goodman Corey S.
Kidd Thomas
Mitchell Kevin J.
Tear Guy
Battison Williams Dupuis
The Regents Of The University Of California
LandOfFree
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