Robust rapid disintegration tablet formulation

A - Human Necessities – 61 – K

Patent

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A61K 9/00 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2686035

A rapidly disintegrating, orally administered tablet or compressed dosage form, comprising ethylcellulose (EC) as a directly compressible binder which enhances tablet robustness as manifested by improved strength, lower friability, lower hygroscopicity and yet, hydrophobic nature notwithstanding, does not retard disintegration, but shortens disintegration time or is disintegration time neutral when co-formulated with disintegrants and other water-soluble excipients such as sugar alcohols.

Le présente invention concerne un comprimé ou une forme de dosage compressée administré oralement et à désintégration rapide, comprenant de l'éthylcellulose (EC) comme liant directement compressible qui augmente la robustesse du comprimé, ce qui se manifeste par plus de solidité, moins de friabilité, une hygroscopie plus faible, et qui, malgré sa nature hydrophobique, ne retarde pas la désintégration mais réduit le temps de désintégration ou reste constant en termes de temps de désintégration lorsque EC est formulée en combinaison avec des désintégrateurs ou d'autres excipients hydrosolubles tels que les alcools de sucre.

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