G - Physics – 06 – K
Patent
G - Physics
06
K
G06K 9/00 (2006.01) A61B 5/00 (2006.01) A61B 5/05 (2006.01) G06T 7/00 (2006.01) G06T 7/40 (2006.01) G01N 1/30 (2006.01) G01N 15/14 (2006.01)
Patent
CA 2448980
A physics based model of the absorption of light by histological stains used to measure the amount of one or more stains at location within tissue is disclosed. The subsequent analysis result in several improvements in the detection of tissue on a slide, improvement to autofocus algorithms so focusing during image acquisition is confined to tissue, improvements to image segmentation and identification of tissued and its features, improvements to the identification of stain where multiple stains are used, and improvements to the quantification of the extent of staining. The invention relates to the application of these improvements to stain detection and quantification to provide for objective comparison between tissues and closer correlation between the presentations of such features and concurrents patterns of gene or protein expression.
Modèle fondé sur la physique de l'absorption de la lumière par les colorations histologiques, utilisé pour mesurer la quantité d'une ou plusieurs colorations dans un endroit à l'intérieur d'un tissu. L'analyse ultérieure permet d'apporter plusieurs améliorations en matière de détection de tissus sur une microplaquette, d'améliorer les algorithmes de mise au point automatique de manière à limiter au tissu la mise au point pendant l'acquisition des, d'améliorer la segmentation d'images et l'identification des tissus et de leurs caractéristiques, l'identification des colorations lorsque plusieurs colorations sont utilisées et, enfin, la quantification des colorations. L'invention concerne l'application de ces améliorations dans la détection et la quantification de colorations permettant une comparaison objective entre plusieurs tissus et une corrélation plus évoluée entre les présentations de ces caractéristiques et les matrices d'expression des gènes ou des protéines concurrentes.
Abdulkarim Othman
Fuhrman Michael
Stone Ronald
Borden Ladner Gervais Llp
Icoria Inc.
Tissueinformatics Inc.
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