Robust sustained release formulations

Details Robust sustained release formulations Robust sustained release formulations

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 31/137 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2652981

Robust sustained release formulations, solid dosage forms comprising robust sustained release formulations, and methods for making and using these fo.pi.nulations and solid dosage forms are provided. Robustness of the sustained release formulation is related to the particle size of the hydrophilic gum. Sustained release formulations resist dose-dumping when ingested with alcohol. The formulations are useful for treating a patient suffering from a condition, e.g., pain. The formulations comprise at least one drug. In one embodiment, the drug is an opioid, e.g., oxymorphone.

L'invention concerne des formulations robustes à libération prolongée, des formes de dosage solides comprenant des formulations robustes à libération prolongée et des procédés de préparation et d'utilisation desdites formulations et des formes de dosage solides. La robustesse de la formulation à libération prolongée est liée à la dimension particulaire de la gomme hydrophile. Les formulations à libération contrôlée résistent à la libération massive lorsqu'elle sont ingérées avec de l'alcool. Les formulations sont utiles pour traiter un patient souffrant d'une affection, p. ex. d'une douleur. Les formulations renferment au moins un médicament. Dans un mode de réalisation, le médicament est un opioïde, p. ex. de l'oxymorphone.

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