Robust sustained release formulations of oxymorphone and...

A - Human Necessities – 61 – K

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A61K 9/20 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2653017

Robust sustained release formulations, solid dosage forms comprising robust sustained release formulations, and methods for making and using these formulations and solid dosage forms are provided. Robustness of the sustained release formulation is related to the particle size of the hydrophilic gum. Sustained release formulations resist dose-dumping when ingested with alcohol. The formulations are useful for treating a patient suffering from a condition, e.g., pain. The formulations comprise at least one drug. In one embodiment, the drug is an opioid, e.g., oxymorphone.

La présente invention concerne des formulations à libération prolongée et stable, des formes de dosage solides contenant les formulations à libération prolongée et stable, et des procédés permettant de fabriquer et d'utiliser ces formulations et formes de dosage solides. La stabilité des formulations à libération prolongée est liée à la dimension des particules de la gomme hydrophile. Les formulations à libération prolongée résistent à une libération massive de la dose lorsqu'elles sont ingérées avec de l'alcool. Les formulations se révèlent utiles pour traiter un patient confronté à un état pathologique, par exemple, la douleur. Les formulations contiennent au moins un médicament. Dans un mode de réalisation, le médicament est un opioïde, comme par exemple, l'oxymorphone.

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