Rodenticide and method of screening

Details Rodenticide and method of screening Rodenticide and method of screening

A - Human Necessities

01

N

A01N 65/44 (2009.01) A01P 11/00 (2006.01) A01P 19/00 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2434267

A rodenticide which is non-toxic to humans, domestic animals and livestock comprises a water-retentive material as the active ingredient and a rodent attractant. Preferably the water-retentive material is cellulosic material. In certain embodiments the water-retentive material comprises alpha-cellulose. In one preferred embodiment the cellulosic material comprises purified cellulose derived from the core of the cob of the DK 446 maize hybrid or from the core of the cob of an agonist of the DK 446 hybrid. It is considered that the unique selective toxicity of such rodenticides arises from the interference with water transport through the gut wall, particularly in the caecum (where cellulose is digested in rats) The caecum is vestigial in humans, who are not therefore affected by such materials. A laboratory method of screening candidate water-retentive materials for rodenticidal activity in the field is disclosed, involving examination of the gut (for compaction and bloating) and the caecum (for impaction).

L'invention concerne un rodenticide non toxique pour l'être humain, les animaux domestiques et le bétail, qui comporte une matière retenant l'eau comme principe actif et une substance attirant les rongeurs. De préférence, la matière retenant l'eau est une matière cellulosique. Dans certaines formes de réalisation, la matière retenant l'eau comporte de l'alpha-cellulose. Dans une forme de réalisation préférée, la matière cellulosique comporte de la cellulose purifiée provenant de la partie centrale de rafle de l'hybride de maïs DK 446 ou de la partie centrale de rafle d'un agoniste de l'hybride DK 446. On considère que l'unique toxicité sélective de ces rodenticides provient de l'interférence avec l'eau de transport traversant la paroi de l'intestin, notamment le caecum (où la cellulose est digérée chez le rat). Le caecum est vestigial chez l'être humain, qui n'est par conséquent pas atteint par ces matières. L'invention concerne un procédé de laboratoire de criblage de matières candidates retenant l'eau pour une activité rodenticide de terrain, qui comporte l'examen de l'intestin (tassement et ballonnement) et du caecum (surcharge).

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