Role of atp-ubiquitin-dependent proteolysis in mhc-1...

Details Role of atp-ubiquitin-dependent proteolysis in mhc-1... Role of atp-ubiquitin-dependent proteolysis in mhc-1...

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 38/55 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2155554

Described herein are methods and drugs that inhibit the processing of antigens for presentation by major histocompatibility complex class I molecules. Specifically, inhibitors of the ATP-ubiquitin dependent proteolytic pathway are described, which can inhibit MHC-I antigen presentation. These methods and drugs may be useful for the treatment of autoimmune diseases and for reducing rejection of organs and graft transplants.

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