Ron antibodies and uses thereof

Details Ron antibodies and uses thereof Ron antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01)

Patent

CA 2712697

The invention relates to antibodies which bind to RON (receptor d'origine nantais, MST1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific antibodies which inhibit RON-mediated pro-survival and tumor pro-liferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific antibodies which block the ability of the ligand, MSP to bind to RON, as well as fragments, variants and derivatives of such antibodies. The inven-tion also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

L'invention porte sur des anticorps qui se lient à RON (récepteur d'origine nantaise, MST1R) et sur leurs utilisations, en particulier dans le diagnostic et le traitement du cancer. L'invention porte sur des anticorps spécifiques qui inhibent les voies de pro-survie et de prolifération tumorale à médiation par RON et des variants, fragments et dérivés de ceux-ci. L'invention porte également sur des anticorps spécifiques qui bloquent l'aptitude du ligand MSP à se lier à RON, ainsi que sur des fragments, variants et dérivés de tels anticorps. L'invention porte également sur des polynucléotides codant pour les anticorps ci-dessus ou fragments, variants ou dérivés de ceux-ci, ainsi que sur des vecteurs et des cellules hôte contenant de tels polynucléotides. L'invention porte en outre sur des procédés de diagnostic et de traitement du cancer utilisant les anticorps de l'invention.

Affiliated with

Also associated with

Rating

Ron antibodies and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ron antibodies and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ron antibodies and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1721012