A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/545 (2006.01)
Patent
CA 2597155
A liquid pharmaceutical composition is contemplated that comprises a pharmaceutically effective amount of a drug dissolved or dispersed in an aqueous medium. The aqueous medium consists essentially of water, about 3% to about 10% w/v polyvinylpyrrolidone, about 60% to about 75% w/v of C3-C6 polyol that includes more than 55% w/v of a non-reducing disaccharide, trisaccharide or tetrasaccharide such as sucrose, optionally about 0.0 1% to about 0.5% w/v of a glycyrrhetic acid, glycyrrhizinate derivative or salt thereof, and one or more flavorants, and preferably includes one or more preservatives. The liquid composition is room temperature stable, and may have a pleasant taste.
L'invention concerne une composition pharmaceutique liquide qui contient une quantité efficace pharmaceutiquement d'un médicament dissous ou dispersé dans un milieu aqueux. Ce milieu aqueux renferme essentiellement de l'eau, entre environ 3 % et environ 10 % en poids de polyvinylpyrrolidone, entre environ 60 % et environ 75 % en poids de C3-C6 polyol qui contient plus de 55 % en poids d'un disaccharide, trisaccharide ou tétrasaccharide non réducteur, tel que le sucrose, facultativement entre environ 0,01 % et environ 0,5 % en poids d'un acide glycyrrhétique, d'un dérivé de glycyrrhizinate ou d'un sel associé, et au moins une essence et, de préférence, au moins un agent de conservation. Ladite composition liquide est stable à température ambiante et elle peut présenter un goût plaisant.
Bhatia Kuljit
Clemente Emmett
Kakkis Emil D.
Patel Bhiku
Sorgi Frank L.
Biomarin Pharmaceutical Inc.
Kirby Eades Gale Baker
Medicis Pediatrics Inc.
Shionogi Pharma Inc.
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