Room temperature storable immunoglobulin preparation for...

A - Human Necessities – 61 – K

Patent

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A61K 39/395 (2006.01) C07K 16/06 (2006.01)

Patent

CA 2251342

A method for producing an immunoglobulin preparation for intravenous injection, which comprises the steps of: fractionating an immunoglobulin-containing solution with 4 to 10 w/v% of polyethylene glycol having a molecular weight of from 1,000 to 10,000, at a pH value of from 4.5 to 6.5, an ionic strength of from 0.0001 to 0.1 M and a temperature of from 0 to 4°C to recover a supernatant fraction; and concentrating the supernatant fraction at a pH of from 3.5 to 5Ø

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