Rors as modifiers of the p21 pathway and methods of use

Details Rors as modifiers of the p21 pathway and methods of use Rors as modifiers of the p21 pathway and methods of use

G - Physics

01

N

G01N 33/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2497790

Human ROR genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of ROR are provided.

Aux fins de l'invention, on a identifié des gènes ROR humains comme modulateurs du trajet p21. Ces gènes peuvent donc être des cibles thérapeutiques pour les troubles associés à une fonction p21 défectueuse. L'invention concerne également des procédés relatifs à l'identification de modulateurs du trajet p21, qui consistent à conduire une analyse pour rechercher les agents modulant l'activité du gène ROR.

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