Rosiglitazone phosphate and polymorphic forms

Details Rosiglitazone phosphate and polymorphic forms Rosiglitazone phosphate and polymorphic forms

C - Chemistry, Metallurgy

07

D

C07D 277/00 (2006.01)

Patent

CA 2554888

The present invention relates to 5-[[4-[2-(methyl-2- pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione phosphate, a novel salt of rosiglitazone and to novel polymorphic forms thereof. The invention is also directed to processes for preparation of rosiglitazone phosphate and its polymorphs. The compounds of the invention are useful for treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.

La présente invention a trait à 5-[[4-[2-(méthyl-2-pyridinylamino)éthoxy]phényl]méthyl]-2,4-thiazolidinedione phosphate, un nouveau sel de rosiglitazone et à de nouvelles formes polymorphes de celui-ci. L'invention a également trait à des procédés de préparation de phosphate de rosiglitazone et ses formes polymorphes. Les composés de l'invention sont utiles pour le traitement et/ou la prophylaxie du diabète sucré, des conditions associées au diabète sucré et à certaines complications en découlant.

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