Rotavirus enterotoxin nsp4 and methods of using same

Details Rotavirus enterotoxin nsp4 and methods of using same Rotavirus enterotoxin nsp4 and methods of using same

A - Human Necessities

61

K

A61K 39/15 (2006.01) A61K 38/00 (2006.01) A61K 39/12 (2006.01) C07H 21/04 (2006.01) C07K 14/14 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2427809

The rotavirus non-structural glycoprotein, NSP4, performs multiple functions in the virus replication cycle, especially during viral morphogenesis. Specifically, NSP4 is an intracellular receptor that mediates the acquisition of a transient membrane envelope during the budding of newly formed subviral particles into the endoplasmic reticulum (ER). The present invention relates to NSP4 and methods of use. More particularly, it relates to the use of NSP4 and fragments thereof (NSP4 114-135, NSP4 120-147, NSP4 112-174, or NSP4 112- 150) as a prevention and/or treatment of rotaviral disease.

L'invention porte sur la glycoprotéine non structurelle de Rotavirus, NSP4, laquelle remplit différentes fonctions dans le cycle de réplication des virus, notamment au cours de la morphogenèse virale. Plus précisément, la NSP4 est un récepteur intracellulaire qui intervient dans le développement d'une enveloppe membranaire transitoire pendant la phase de bourgeonnement de nouvelles particules sous-virales dans le réticulum endoplasmique (ER). Ladite invention porte sur la NSP4 et ses méthodes d'utilisation. Elle a plus particulièrement trait à l'utilisation de la NSP4 et de fragments de celle-ci (NSP4 114-135, NSP4 120-147, NSP4 112-174, ou NSP4 112-150) dans la prévention ou le traitement de maladies à Rotavirus.

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