Rsk inhibitors and therapeutic uses thereof

Details Rsk inhibitors and therapeutic uses thereof Rsk inhibitors and therapeutic uses thereof

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/352 (2006.01) A61K 31/7048 (2006.01) A61K 36/24 (2006.01) C07H 17/04 (2006.01) C12N 9/12 (2006.01) C12N 9/99 (2006.01) C12Q 1/04 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2488864

The present invention is directed to novel compounds and compositions that have Rsk specific inhibitory activity. In addition, inhibition of Rsk by the present compounds has been discovered to halt the proliferation of cancer cell lines while having little effect on the proliferation rate of normal cells. Therefore, the present invention identifies Rsk as a target for therapeutic intervention in diseased states in which the disease or the symptoms can be ameliorated by inhibition of Rsk catalytic activity.

La présente invention concerne de nouveaux composés et de nouvelles compositions qui présentent une activité inhibitrice spécifiquement dirigée contre Rsk. On a en outre remarqué que l'inhibition de Rsk par les composés selon la présente invention, ont pour effet de stopper la prolifération des lignées cellulaires cancéreuses tout en n'ayant qu'un faible effet sur la vitesse de prolifération des cellules normales. Par conséquent, cette invention permet d'identifier Rsk en tant que cible pour l'intervention thérapeutique dans les états pathologiques dans lesquels la maladie ou les symptômes peuvent être améliorés par l'inhibition de l'activité catalytique Rsk.

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