Rspondins as modulators of angiogenesis and vasculogenesis

Details Rspondins as modulators of angiogenesis and vasculogenesis Rspondins as modulators of angiogenesis and vasculogenesis

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2664828

The present invention relates to the use of Rspondins, particularly Rspondin2 (Rspo2) or Rspondin3 (Rspo3) or Rspondin nucleic acids, or regulators or effectors or modulators of Rspondin e.g. Rspo2 and/or Rspo3 to promote or inhibit angiogenesis and/or vasculogenesis, respectively. The invention is based on the demonstration that Rspo3 and Rspo2 are angiogenesis promoters, and the identification of Rspo2 and 3 as positive regulators of vascular endothelial growth factor (VEGF). These results indicate a major role for Rspondins, particularly Rspo3 and/or Rspo2 in the signalling system during angiogenesis. The invention also relates to the use regulators or effectors or modulators of Rspondin3, including agonists and antagonists, in the treatment of conditions where treatment involves inhibiting or promoting angiogenesis and/or vasculogenesis.

Cette invention concerne l'utilisation de Rspondins, en particulier Rspondin2 (Rspo2) ou Rspondin3 (Rspo3) ou des acides nucléiques de Rspondin, ou des régulateurs, des effecteurs ou des modulateurs de Rspondin, par exemple Rspo2 et/ou Rspo3 pour promouvoir ou inhiber respectivement l'angiogenèse et/ou la vasculogenèse. La présente invention est fondée sur la démonstration selon laquelle Rspo3 et Rspo2 sont des promoteurs de l'angiogenèse, et sur l'identification de Rspo2 et Rspo3 comme étant des régulateurs positifs du facteur de croissance de l'endothélium vasculaire (VEGF). Ces résultats indiquent que les Rspondins, en particulier Rspo3 et/ou Rspo2, jouent un rôle prépondérant dans le système de signalisation lors de l'angiogenèse. Cette invention se rapporte en outre à l'utilisation de régulateurs, d'effecteurs ou de modulateurs de Rspondin3, y compris d'agonistes ou d'antagonistes, pour traiter des états, ce traitement consistant à inhiber et/ou favoriser l'angiogenèse et/ou la vasculogenèse.

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