C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 39/155 (2006.01) C07K 14/135 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C07K 16/10 (2006.01)
Patent
CA 2743012
The present invention relates to the field of isolation of enveloped virus- based virus- like particles (VLPs) free of infectious agents. In preferred examples, the field includes methods of inactivation of infectious agents that do not adversely affect the immunogenicity of the enveloped virus-based VLPs. In certain embodiments, the enveloped virus-based VLPs are produced in insect cell based expression systems.
La présente invention concerne le domaine de l'isolement de particules de type viral (VLP) à base de virus à enveloppe exemptes d'agents infectieux. Dans des exemples préférés, le domaine comprend des procédés d'inactivation d'agents infectieux qui n'affectent pas de manière indésirable l'immunogénicité des VLP à base de virus à enveloppe. Dans certains modes de réalisation, les VLP à base de virus à enveloppe sont produits dans des systèmes d'expression à base de cellules d'insecte.
Gowling Lafleur Henderson Llp
Ligocyte Pharmaceuticals Inc.
LandOfFree
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