(s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4­ho...

Details (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4­ho... (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4­ho...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/551 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2589237

(S)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4~homopiperazine hydrochloride dihydrate; a process for producing the dihydrate; and a medicinal composition containing the dihydrate. This compound has lower hygroscopicity than anhydrous crystals of (S)-(-)-1-(4-fluoroisoquinolin-5- yl)sulfonyl-2-methyl~1,4-homopiperazine hydrochloride and is superior in chemical stability. It is hence useful as a medicine.

L'invention concerne un dihydrate d'hydrochlorure (S) - (-) 1 (4-fluoroisoquinoline-5-yl)sulfonyle-2-méthyl-1,4-homopipérazine; un procédé de production du dihydrate; et une composition médicamenteuse contenant ledit dihydrate. Ce composé présente une hygroscopicité plus faible que les cristaux anhydres de l'hydrochlorure (S) - (-) 1 (4-fluoroisoquinoline-5-yl)sulfonyle-2-méthyl-1,4-homopipérazine et sa stabilité chimique est supérieure, d'où son utilité en tant que médicament.

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