S-(+)-adenosylmethionine and...

Details S-(+)-adenosylmethionine and... S-(+)-adenosylmethionine and...

C - Chemistry, Metallurgy

07

H

C07H 19/173 (2006.01) A61K 31/70 (2006.01) C07H 19/073 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2213099

Molecular Complexes, comprising of S-(+)-adenosylmethionine and 3'-azido-2',3'-dideoxy nucleosides are prepared, and shown to have synergistic inhibitory effects on the replication of human-immunodeficiency virus 1 & 2 in vitro and in vivo, particularly on the reverse transcriptase, and having a high therapeutic index.

Préparation de complexes moléculaires, à base de S-(+)-adénosylméthionine et de 3'-azido-2',3'-didésoxynucléosides; ils ont un effet synergiste inhibiteur sur la réplication in vitro et in vivo du virus de l'immunodéficience humaine 1 et 2, particulièrement sur la transcriptase inverse, et possèdent un haut indice thérapeutique.

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