(s)-alkyl 3-(thien-2-ylthio)butyrate and analogs and...

Details (s)-alkyl 3-(thien-2-ylthio)butyrate and analogs and... (s)-alkyl 3-(thien-2-ylthio)butyrate and analogs and...

C - Chemistry, Metallurgy

07

D

260/329.4

C07D 333/34 (2006.01)

Patent

CA 2040605

284/WHN23 17837 TITLE OF THE INVENTION (S)-ALKYL 3-(THIEN-2-YLTHIO)BUTYRATE AND ANALOGS AND SYNTHESIS THEREOF ABSTRACT OF THE DISCLOSURE (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs are intermediates in the synthesis of the chiral (S,S)-5,6-dihydro-4-ethylamino-6-methyl- 4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide and analogs thereof, topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma.

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