(s)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide

Details (s)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide (s)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide

C - Chemistry, Metallurgy

07

D

260/324

C07D 207/27 (2006.01)

Patent

CA 1235129

ABSTRACT OF THE DISCLOSURE: The invention relates to (S)-alpha-ethyl-2-oxo-1- pyrrolidineacetamide of the formula Image and its preparation either by reacting (S)-alpha-ethyl-2-oxo-1- pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (S)-2- amino-butanamide of the formula X-CH2CH2-Y-NHCH(C2H5)CONH2 wherein Y is a -CH2-radical when X represents a ZOOC- radical and Y is a -CO- radical when X represents a HalCH2- radical, Z being a C1-C4 alkyl radical and Hal a halogen atom. This laevorotatory enantiomer has been found to have significantly higher protective activity against hypoxia and ischemia than the correspondint racemate.

481512

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