S-diastereomer of n ¬(2-hydroxypropyl)aryl|adenosines

Details S-diastereomer of n ¬(2-hydroxypropyl)aryl|adenosines S-diastereomer of n ¬(2-hydroxypropyl)aryl|adenosines

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/167 (2006.01) A61K 31/70 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2001280

Abstract A novel S diastereomer of an N6-[(2-hydroxypropyl)aryl] adenosine, which diastereomer exhibits fewer CNS side effects than the racemate, but with no decrease in cardiovascular activity. The invention further provides for compositions incorporating the diastereomer, and methods of its use, as well as pharmaceutically acceptable salts thereof.

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