S-lansoprazole compositions and methods

Details S-lansoprazole compositions and methods S-lansoprazole compositions and methods

A - Human Necessities

61

K

A61K 31/44 (2006.01)

Patent

CA 2320902

Methods and compositions are disclosed utilizing optically pure (-) lansoprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of lansoprazole. The optically pure (-) isomer is also useful for the treatment of gastroesophageal reflux. (-) Lansoprazole is an inhibitor of H+ release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

L'invention concerne des procédés et des compositions de lansoprazole (-) optiquement pur, utilisées pour traiter les ulcères chez l'homme, tout en réduisant sensiblement le risque concomitant de réactions indésirables associées au mélange racémique du lansoprazole. L'isomère (-) est également utilisé pour traiter le reflux gastro-oesophagien. Le lansoprazole (-) est un inhibiteur de libération de H?+¿ et est également utilisé pour traiter d'autres états associés à l'hypersécrétion gastrique tels que le syndrome de Zollinger-Ellison.

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