S-nitrosothiols as smooth muscle relaxants and therapeutic...

Details S-nitrosothiols as smooth muscle relaxants and therapeutic... S-nitrosothiols as smooth muscle relaxants and therapeutic...

C - Chemistry, Metallurgy

07

C

C07C 313/36 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 38/06 (2006.01) C07C 317/28 (2006.01) C07C 323/64 (2006.01) C07C 381/00 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2107219

S-nitrosothiols exert a potent relaxant effect, mediated by guanylate cyclase, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosah Thus, S- nitrosothiols may be used for the treatment or prevention of disorders associated with relaxation of smooth muscle, such as airway obstruction, and other respiratory disorders, bladder dysfunction, premature labor and impotence, Additionally, S-nitrosothiols may be used to alleviate smooth muscle contraction and spasm, and thus facilitate procedures involving diagnostic instrumentation, such as endoscopy, bronchoscopy, laparoscopy and cystoscopy. Figure 3 shows the relaxation effects of various S-nitrosbthiols on guinea pig trachea.

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