S-omeprazole (esomeprazole) inclusion complex with...

Details S-omeprazole (esomeprazole) inclusion complex with... S-omeprazole (esomeprazole) inclusion complex with...

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61K 31/724 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2449769

An inclusion complex comprises a substantially pure optical isomer of a benzimidazole compound and cyclodextrin. The complex preferably comprises S- omeprazole and .beta.-cyclodextrin and is made by adding the cyclodextrin to an aqueous solution of the active material, and then isolating the complex from the solution.

L'invention concerne un complexe d'inclusion comprenant un isomère optique sensiblement pur d'un composé benzimidazole et de cyclodextrine. Le complexe comprend de préférence du S-oméprazole et de la .beta.-cyclodextrine et est formé par addition de cyclodextrine dans une solution aqueuse de la matière active, puis par isolement du complexe de la solution.

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