S-oxide and s,s-dioxide tetrahydrothiopyran...

Details S-oxide and s,s-dioxide tetrahydrothiopyran... S-oxide and s,s-dioxide tetrahydrothiopyran...

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) A61K 31/38 (2006.01) A61K 31/42 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2309026

The present invention provides compounds of formula (I) and formula (II) useful as antimicrobial agents wherein R1 is methyl, ethyl, cyclopropyl, or dichloromethyl; R2 and R3 are independently hydrogen or fluoro; R4 is ethyl or dichloromethyl. The invention also relates to a novel assay for determining the inhibitory activity of oxazolidinones to human monoamine oxidase.

Composés de formule (I) et de formule (II) utiles en tant qu'agents antimicrobiens, dans lesquelles R1 est méthyle, éthyle, cyclopropyle ou dichlorométhyle, R2 et R3 sont indépendamment hydrogène ou fluoro, R4 est éthyle ou dichlorométhyle. La présente invention concerne en outre une nouvelle analyse permettant de déterminer l'activité inhibitrice d'oxazolidinones sur la monoamine oxydase humaine.

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