S-procyclidine for treating urinary incontinence

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/40 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2315843

A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)- procyclidine. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-procyclidine, or a pharmaceutically acceptable salt thereof, substantially free of the (R)-procyclidine enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-procyclidine, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

Cette invention a trait à une méthode visant à traiter l'incontinence urinaire, notamment l'incontinence résultant d'une instabilité du détrusor de la vessie, laquelle méthode fait appel à la procyclidine-(S) enrichie par énantiomères. Cette méthode consiste à administrer une quantité efficace du point de vue thérapeutique de procyclidine-(S) enrichie par énantiomères ou d'un sel de celle-ci, acceptable du point de vue pharmaceutique, quasiment exempt d'énantiomère de procyclidine-(R). L'invention porte également, d'une part, sur des compositions pharmaceutiques permettant de traiter l'incontinence urinaire et renfermant de la procyclidine-(S) enrichie par énantiomères ou un sel de celle-ci, acceptable du point de vue pharmaceutique et, d'autre part, sur un excipient approprié.

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