S-rabeprazole compositions and methods

Details S-rabeprazole compositions and methods S-rabeprazole compositions and methods

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61P 1/04 (2006.01) A61P 17/06 (2006.01)

Patent

CA 2330324

Methods and compositions are disclosed utilizing optically pure (-) rabeprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of rabeprazole. The optically pure (-) isomer is also useful for the treatment of gastroesophageal reflux. (-) Rabeprazole is an inhibitor of H+ release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

L'invention concerne des procédés et des compositions dont le principe repose sur l'utilisation du produit optiquement pur S (-) rabéprazole, qui permet de traiter les ulcères chez l'homme tout en réduisant sensiblement le risque concomitant des effets néfastes associés au conglomérat racémique de rabéprazole. L'isomère optiquement pur S (-) est également utile pour le traitement du reflux gastro-oesophagien. En tant qu'inhibiteur de la libération de H?+¿, le S (-) rabéprazole intervient utilement dans le traitement d'autres affections liées à l'hypersécrétion gastrique, comme par exemple le syndrome de Zollinger-Ellison.

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