A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/139
A61K 39/395 (2006.01) C07K 16/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1153695
Abstract of the Disclosure The present invention is directed to an S-sulfonated immunoglobuiin composition comprising an S-sulfonated immunoglobulin and as an aggregation preventing agent or an aggregate dissociating agent, therefor, about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin of a water-soluble acid addition salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optional- ly carboxyl groups smaller in number than the basic nitrogen atoms and having a pKb at 25°C of not more than 7. There is also provided a process for producing an S-sulfonated immunoglobulin composition having a high monomer content, Which comprises contacting an S-sulfonated immuno- giobulin in aqueous solution with about 1 to about 600% by weight, based on the weight of the S-sulfonated immuno- globulin, of the water-soluble acid addition salt, or reacting an immunoglobulin in aqueous solution with a compound capable of yielding a sulfite ion in water and an oxidizing agent in the presence of about 1 to about 600% by weight, based on the immunoglobulin of the water-soluble acid addition salt.
359215
Fukumoto Yuji
Ono Syoji
Yoshida Tsunemasa
Chemo-Sero-Therapeutic Research Institute (the)
Smart & Biggar
Teijin Limited
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