A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2520515
The present invention relates to a method and composition for inducing lymphocyte proliferation and migration, and for reducing the risks of microbial infections in patients immuno-supressed. The present invention particularly relates to the use of S100 protein, such as MRP, to induce the proliferation, differentiation and release of immune cells from bone marrow. More particularly, S100A8, S100A9, S100A12 and S100A8/A9 are administered to patients with lowered neutrophil blood concentrations.
L'invention concerne un procédé et une composition destinés à induire la prolifération et la migration des lymphocytes, et à réduire le risque d'infections microbiennes chez les patients à immunosuppression. L'invention concerne en particulier l'utilisation d'une protéine S100, telle qu'une MRP, pour induire la prolifération, la différenciation et la libération de cellules immunitaires de la moelle osseuse. L'invention concerne plus particulièrement l'administration de S100A8, S100A9, S100A12 et de S100A8/A9 à des patients présentant des concentrations sanguines de neutrophiles réduites.
Rouleau Pascal
Ryckman Carle
Tessier Philippe
Vandal Karen
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universite Laval
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