A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/7105 (2006.01) A61K 38/02 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2573596
The present invention is directed to compounds, composition and method for reducing or inhibiting the differentiation or development of progenitor blood cells into leukemia cells, Particularly, the invention describes the use of inhibitors of S100 proteins, including myeloid related proteins (MRP). Inhibition of the activity or synthesis of S100 proteins results in the reduction or inhibition of the production or proliferation of leukemia cells.
L'invention porte sur des composés, compositions et procédés réduisant ou inhibant la différentiation ou le développement de cellules sanguines progénitrices dans des cellules leucémiques, décrit et en particulier l'utilisation d'inhibiteurs des protéines S100, dont les protéines liées à la leucémie myéloïde (MRP). L'inhibition ou la synthèse des protéines S100 se traduit par la réduction ou l'inhibition de la production ou de la prolifération des cellules leucémiques.
Rouleau Pascal
Ryckman Carle
Tessier Philippe
Vandal Karen
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universite Laval
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