S1p receptor modulating compounds and use thereof

Details S1p receptor modulating compounds and use thereof S1p receptor modulating compounds and use thereof

C - Chemistry, Metallurgy

07

D

C07D 405/10 (2006.01) A61K 31/395 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2630714

The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

La présente invention concerne des composés représentés par la formule générale (I) qui présentent une activité en tant qu'agents modulateurs du récepteur S1P, ainsi que l'utilisation desdits composés afin de traiter des maladies associées à une activité du récepteur S1P inappropriée. Lesdits composés peuvent être utilisés en tant qu'immunomodulateurs, par ex., pour traiter ou prévenir des maladies telles que les affections auto-immunes et liées à l'immunité, notamment le lupus érythémateux disséminé, les maladies intestinales inflammatoires telles que la maladie de Crohn et la rectocolite hémorragique, le diabète de type I, l'uvéite, le psoriasis, la myasthénie grave, la polyarthrite rhumatoïde, la néphrite non glomérulaire, l'hépatite, la maladie de Behçet, la glomérulonéphrite, le purpura thrombocytopénique chronique, l'anémie hémolytique, l'hépatite et le granulome de Wegner; et pour traiter d'autres affections.

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