S1p receptors modulators

Details S1p receptors modulators S1p receptors modulators

C - Chemistry, Metallurgy

07

C

C07C 215/68 (2006.01) A61K 31/136 (2006.01) A61K 31/137 (2006.01) A61K 31/4045 (2006.01) A61K 31/4245 (2006.01) A61K 31/47 (2006.01) A61K 31/551 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07C 215/10 (2006.01) C07C 215/18 (2006.01) C07C 215/52 (2006.01) C07C 217/60 (2006.01) C07C 217/62 (2006.01) C07C 217/80 (2006.01) C07C 225/16 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/38 (2006.01) C07D 209/44 (2006.01) C07D 215/06 (2006.01) C07D 215/20 (2006.01) C07D 217/04 (2006.01) C07D 22

Patent

CA 2739901

The invention relates to novel compounds that have S1P receptor modulating activity and, preferably, apoptotic activity and/or anti proliferative activity against cancer cells and other cell types. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, cancer. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as cancer.

Linvention concerne de nouveaux composés qui possèdent une activité de modulation des récepteurs S1P et de préférence, une activité apoptosique et/ou une activité antiproliférative contre des cellules cancéreuses et dautres types cellulaires. En outre, linvention concerne une substance pharmaceutique comprenant au moins un composé de linvention pour le traitement de maladies et/ou daffections provoquées par ou associées à une activité de modulation ou une expression inappropriée des récepteurs S1P, par exemple, un cancer. Un autre aspect de linvention concerne lutilisation dune substance pharmaceutique comprenant au moins un composé de linvention pour la fabrication dun médicament destiné au traitement de maladies et/ou daffections provoquées par ou associés à une activité de modulation ou une expression inappropriée des récepteurs S1P, tel quun cancer.

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