S3n chelating compounds for the radiolabeling of ligands,...

Details S3n chelating compounds for the radiolabeling of ligands,... S3n chelating compounds for the radiolabeling of ligands,...

C - Chemistry, Metallurgy

07

K

C07K 14/465 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07B 59/00 (2006.01) C07C 323/59 (2006.01) C07D 339/06 (2006.01) C07D 495/04 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) C07K 14/36 (2006.01) G01N 33/534 (2006.01)

Patent

CA 2165538

Novel chelating compounds and the corresponding radionuclide metal chelates are useful for radiolabeling proteins such as antibodies, ligands such as biotin and anti-ligands such as streptavidin with radionuclide metals such as 99mTc, 186Re, and 188Re. The radiolabeled proteins, ligands and anti-ligands have diagnostic or therapeutic use, depending on the radionuclide metal chosen.

De nouveaux composés chélatants et les chélates correspondants de métaux de radionuclides sont efficaces pour le radiomarquage de protéines, telles que des anticorps, de ligands, tels que biotine, et d'antiligands, tels que streptavidine, avec des métaux de radionuclides, tels que <99m>Tc, <186>Re et <188>Re. Les protéines, les ligands et les antiligands radiomarqués possèdent une utilisation diagnostique ou thérapeutique en fonction du métal de radionuclide sélectionné.

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