A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/095 (2006.01) A61K 39/116 (2006.01)
Patent
CA 2594524
The invention provides compositions comprising a combination of two or more monovalent conjugates, each of said two or more monovalent conjugates comprising a carrier protein comprising T cell epitopes from two or more pathogens conjugated to saccharide antigen. The invention also provides a multivalent conjugate comprising two or more antigenically distinct saccharide antigens conjugated to the same carrier protein molecule, wherein the carrier protein comprises T cell epitopes from two or more pathogens. Further compositions comprise one or more of said monovalent conjugates and one or more of said multivalent conjugates. The invention further provides methods for making said compositions and uses for said compositions. The examples involve the conjugation of Nl 9 carrier protein to meningococcal oligosaccharides.
L'invention concerne des compositions comprenant une combinaison d'au moins deux conjugués monovalents présentant individuellement une protéine porteuse renfermant des épitopes de lymphocytes T provenant d'au moins deux pathogènes conjugués à un antigène de saccharide. L'invention concerne également un conjugué multivalent comprenant au moins deux antigènes de saccharide distincts sur le plan antigènique conjugués à la même molécule de la protéine porteuse, celle-ci comprenant des épitopes de lymphocytes T provenant d'au moins deux pathogènes. D'autres compositions comprennent au moins un de ces conjugués monovalents et au moins un de ces conjugués multivalents. L'invention concerne enfin des procédés de préparation de ces compositions et des utilisations de celles-ci.
Baraldo Karin
Del Giudice Giuseppe
Borden Ladner Gervais Llp
Novartis Vaccines And Diagnostics S.r.l.
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