Saccharide derivatives and processes for their manufacture

Details Saccharide derivatives and processes for their manufacture Saccharide derivatives and processes for their manufacture

C - Chemistry, Metallurgy

07

H

167/199, 260/228

C07H 3/02 (2006.01) A61K 31/70 (2006.01) C07H 5/10 (2006.01) C07H 15/04 (2006.01)

Patent

CA 1271743

4-15727/+ Saccharide derivatives and processes for their manufacture Abstract Mono- and di-saccharidyl derivatives that are linked via a bridge member to a cephalin derivative, of the formula I, and processes for their manufacture are described. Image (I) In the formula, R represents a) aldohexosyl, b) D-aldo- hexosyl that is glycosidically linked in the 4- or the 6-position to D-aldohexosyl, c) aldopentosyl, d) 6-deoxy- aldohexosyl or e) 2-acetylamino-2-deoxy-D-aldohexosyl, it being possible for free hydroxy groups present in the radicals mentioned under a) to e) above to be peracetyl- ated, X represents oxygen or sulphur, Y represents alkylene having up to 10 carbon atoms in which from 1 to 3 non-terminal methylene groups may be replaced by oxygen, by carbonylimino or by carbonyloxy, R2 represents hydro- gen, carboxy, lower alkoxycarbonyl, benzyloxycarbonyl or carbamoyl, R3 represents hydrogen and R4 represents a 1,2-dihydroxy-ethyl, 2-hydroxy-ethyl or hydroxymethyl group in which at least one hydroxy group is esterified by an unsubstituted aliphatic C10-24-carboxylic acid and in which the other hydroxy group, if present, is free or esterified by an aliphatic C2-24-carboxylic acid, or R3 and R4 each represents a hydroxymethyl group esterified by an unsubstituted aliphatic C10-24-carboxylic acid. These compounds can be used as medicaments, for example for the prophylaxis and therapy of virus infections.

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