Safe mutant viral vaccines

Details Safe mutant viral vaccines Safe mutant viral vaccines

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61K 39/295 (2006.01) C07K 14/18 (2006.01)

Patent

CA 2533877

The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic acids contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.

La présente invention a trait à des vaccins sécurisés et des procédés de préparation de tels vaccins. Les vaccins de la présente invention contiennent au moins deux virus mutants de la même famille ou des molécules d'acides nucléiques codant pour de tels virus, chacun des deux virus ou des acides nucléiques codants contenant une mutation procurant un phénotype souhaitable et les mutations dans les virus se trouvant dans le même site génomique de sorte que les virus mutants ne peuvent se recombiner entre eux pour éliminer les mutations.

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