Safety-catch linkers

Details Safety-catch linkers Safety-catch linkers

C - Chemistry, Metallurgy

07

D

C07D 295/24 (2006.01) C07B 61/00 (2006.01) C07C 271/60 (2006.01) C07D 295/215 (2006.01) C07D 305/14 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2260472

Safety-catch linkers and methods for use of safety-catch linkers in solid phase and combinatorial solid phase synthesis are provided. Safety-catch linkers covalently bonded to solid supports are also provided. The safety-catch linkers are stable to a wide variety of synthetic protocols so that substrates, such as amines, thiols and alcohols, are cleaved from the linkers under mild conditions. The safety-catch linkers are useful in solid phase synthesis and modification of natural products and other complex organic substrates.

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