Saframycins, analogues and uses thereof

Details Saframycins, analogues and uses thereof Saframycins, analogues and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 471/18 (2006.01) A61K 31/495 (2006.01) A61K 31/4985 (2006.01) A61K 31/4995 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2447553

In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof (I), In another aspect, the present invention provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. In yet another aspect, the present invention provides methods for treating cancer comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof.

Au vue de la nécessité de mettre au point de nouveaux agents thérapeutiques et de nouveaux procédés efficaces pour la synthèse desdits agents, l'invention porte sur de nouveaux composés de formule générale (I) et des procédés permettant la synthèse de ces composés. Selon une autre variante, l'invention concerne des compositions pharmaceutiques contenant un composé de formule (I) et un support pharmaceutiquement acceptable. Selon une autre variante, l'invention concerne des procédés de traitement du cancer consistant à administrer une quantité thérapeutiquement efficace d'un composé de formule (I) à un patient atteint de la maladie.

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