Salicylamide esters having therapeutical activity, process...

Details Salicylamide esters having therapeutical activity, process... Salicylamide esters having therapeutical activity, process...

C - Chemistry, Metallurgy

07

D

260/474.2, 260/2

C07D 213/80 (2006.01) C07C 103/20 (1980.01)

Patent

CA 1134366

ABSTRACT OF THE DISCLOSURE Esters of salicylamide with anti-inflammatory and analgesic action are disclosed. These ester have the follow- ing general formula: Image (I) wherein R is a radical of an acid selected from the group consisting of d-2-(6'-methoxy-2'-naphthyl)-propionic acid, 2-{[3-(trifluoromethyl)-phenyl]-amino} -3-pyridin- carboxylic acid, 2-(4-isobutyl-phenyl)-propionic acid, 4-allyloxy-3-chloro-phenylacetic acid, 2-(3-benzoylphenyl)- propionic acid, mefenamic acid and flufenamic acid. The process for preparing these these esters comprises reacting a halide, preferably a chloride of the desired acid, with a solution of salicylamide.

348495

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