C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 257/18 (2006.01) A61K 31/155 (2006.01) A61P 7/02 (2006.01) A61P 35/00 (2006.01) C07C 279/18 (2006.01) C07D 209/48 (2006.01) C07D 213/75 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 307/14 (2006.01) C07D 317/60 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2394639
The present invention provides novel compounds of Formula (I), its prodrug forms, or pharmaceutically acceptable salts thereof. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals. The present invention also provides a process for the selective acylation of an amino group.
L'invention concerne des nouveaux composés correspondant à la formule (I), des formes de promédicaments contenant ces composés, ainsi que des sels de ceux-ci, acceptables sur le plan pharmacologique. Les composés de l'invention constituent des inhibiteurs des sérines protéases, de l'urokinase, du facteur Xa et/ou du facteur VIIa, et ils sont utiles en tant qu'agents anticancéreux et/ou en tant qu'anticoagulants dans le traitement ou la prévention d'attaques thromboemboliques, chez les mammifères. L'invention concerne encore un procédé d'acylation sélective d'un groupe amino.
Allen Darin Arthur
Mcgee Danny Peter Claude
Spencer Jeffrey R.
Axys Pharmaceuticals
Sim & Mcburney
LandOfFree
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