Salicylanilide modified peptides for use as oral therapeutics

Details Salicylanilide modified peptides for use as oral therapeutics Salicylanilide modified peptides for use as oral therapeutics

A - Human Necessities

61

K

A61K 47/16 (2006.01) A61K 38/10 (2006.01)

Patent

CA 2697504

This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues can be reacted with a therapeutically active peptide to produce a modified peptide complex that shows increased resistance to proteolysis and that shows higher bioactivity when orally administered than the unmodified peptide.

L'invention concerne une découverte surprenante selon laquelle des salicylanilides, par exemple des niclosamides et/ou des analogues de niclosamides, peuvent être mises en réaction avec un peptide thérapeutiquement actif pour produire un complexe peptidique modifié qui, administré par voie orale, présente une résistance accrue à la protéolyse et une bioactivité supérieure à celle d'un peptide correspondant non modifié.

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