Salmeterol superfine formulation

Details Salmeterol superfine formulation Salmeterol superfine formulation

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 31/05 (2006.01) A61K 31/11 (2006.01) A61K 31/135 (2006.01) A61K 31/4704 (2006.01) A61K 31/485 (2006.01) A61K 45/06 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01)

Patent

CA 2503183

The present invention relates to a pharmaceutical formulation for use in the administration of a long-acting .beta.2-agonist by inhalation. In particular this invention relates to a chemically stable, highly efficient salmeterol HFA solution formulation to be administered by pressurised metered dose inhalers (pMDIs) characterized by a deep lung penetration. The invention also relates to methods for the preparation of said formulation and to its use in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).

L'invention se rapporte à une préparation pharmaceutique à utiliser dans l'administration d'un antagoniste .beta.2 à action prolongée par inhalation. En particulier, cette invention se rapporte à une préparation de solution HFA de salmétérol hautement efficace et chimiquement stable destinée à être administrée au moyen d'aérosols-doseurs pressurisés (PMDI) caractérisés par une pénétration pulmonaire profonde. L'invention se rapporte en outre à des procédés de production de cette préparation, ainsi qu'à son utilisation pour traiter des maladies respiratoires telles que l'asthme et la bronchopneumopathie chronique obstructive (BPCO).

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