Salmonella secreted proteins and uses thereof

Details Salmonella secreted proteins and uses thereof Salmonella secreted proteins and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/112 (2006.01) A61K 39/385 (2006.01) C07K 14/255 (2006.01) C07K 16/12 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 1/36 (2006.01) C12N 9/16 (2006.01) C12N 15/55 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2237581

Substantially pure Salmonella secreted proteins (Ssp), the secretion of which is dependent upon the expression of PrgH; methods of diagnosing Salmonella infection; and live attenuated vaccine strains in which Ssp secretion is decreased.

Cette invention concerne des protéines sécrétées par la Salmonelle (Ssp), sensiblement pures, dont la sécrétion dépend de l'expression du gène PrgH. L'invention concerne en outre des procédés permettant de diagnostiquer une infection par la Salmonelle ainsi que des souches de vaccins vivants atténués par une sécrétion réduite de protéines Ssp.

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